Dry powder inhalers (DPIs) for Salbutamol sulphate were developed with a view to treat bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema effectively. The formulations were prepared with different grades of Lactose monohydrate like Flowlac 100, lactohale 300, Sorbolac 400, Inhalac 230, Respitose SV003, and DCL11. The formulations were evaluated for physical appearance, average fill weight per capsule, content uniformity, uniformity of delivered dose , emitted dose, moisture content, assay and locking length. The influence of composition of DPI and overages on performance of DPI was studied. The better fine particle fraction was obtained from the DPIs formulated with 10:90 ratio of fine lactose (Lactohale 300): coarsey lactose (Respitose SV003) and having 20%w/w overages.
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